The soul that sets up its rest, and makes it its great concernment to walk humbly with God, is brought to His foot, bent to His will, is ready for His disposal; and whatever God does in the world with himself, his, or others, he hath peace and quietness in it. His own will is gone, the will of God is his choice; his great concernment lies not in anything that can perish, that can be lost.
When a man shall see, in the worst state and condition, that his great concernment is safe; that though all is lost, God, who is all, is not lost; that this can never be taken from him;—it fills his heart with delight. Is he in prosperity? he fears not the loss of that which he most values. Is he in adversity? yet he can walk with God still; which is his all. He can therefore glory in tribulations, rejoice in afflictions;—his treasure, his concernment is secure.
~John Owen
from a sermon entitled Of Walking Humbly With God, volume 9 of Works, page 129